Heldin C H, Ostman A, Rönnstrand L
Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden.
Biochim Biophys Acta. 1998 Aug 19;1378(1):F79-113. doi: 10.1016/s0304-419x(98)00015-8.
Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility by binding to two related protein tyrosine kinase receptors. Ligand binding induces receptor dimerization and autophosphorylation, allowing binding and activation of cytoplasmic SH2-domain containing signal transduction molecules. Thereby, a number of different signaling pathways are initiated leading to cell growth, actin reorganization migration and differentiation. Recent observations suggest that extensive cross-talk occurs between different signaling pathways, and that stimulatory signals are modulated by inhibitory signals arising in parallel.
血小板衍生生长因子（PDGF）通过与两种相关的蛋白酪氨酸激酶受体结合，对细胞生长和运动发挥其刺激作用。配体结合诱导受体二聚化和自身磷酸化，从而允许结合并激活含有细胞质SH2结构域的信号转导分子。由此，启动了许多不同的信号通路，导致细胞生长、肌动蛋白重组、迁移和分化。最近的观察结果表明，不同信号通路之间发生广泛的相互作用，并且刺激信号受到并行产生的抑制信号的调节。
