胸外科手术中头孢拉定的血清及肺组织水平
Serum and lung tissue levels of cephradine in thoracic surgery.
作者信息
Kiss I J, Faragó E, Pintér J
出版信息
Br J Clin Pharmacol. 1976 Oct;3(5):891-5. doi: 10.1111/j.1365-2125.1976.tb00643.x.
Abstract
Serum and lung tissue levels in fifteen patients who underwent thoracic surgery were determined by the agar-diffusion plate method after i.m. administration of cephradine (500 mg). The mean value of the serum level 30 to 120 min after administration was 6.5 mug/ml, the mean lung tissue level was 2.6 mug/g. The lung tissue levels reached 40% of the simultaneous serum level. Four patients received cephradine for the treatment of post-operative chest infections. This antibiotic has an important therapeutic role in cases of thoracic-surgical infections.
摘要
对15例接受胸外科手术的患者，在肌内注射头孢拉定（500毫克）后，采用琼脂扩散平板法测定血清和肺组织水平。给药后30至120分钟血清水平的平均值为6.5微克/毫升，肺组织平均水平为2.6微克/克。肺组织水平达到同期血清水平的40%。4例患者接受头孢拉定治疗术后胸部感染。这种抗生素在胸外科感染病例中具有重要的治疗作用。
相似文献
1
Serum and lung tissue levels of cephradine in thoracic surgery.胸外科手术中头孢拉定的血清及肺组织水平
Br J Clin Pharmacol. 1976 Oct;3(5):891-5. doi: 10.1111/j.1365-2125.1976.tb00643.x.
2
Cephradine concentrations in serum, pleural fluid, pleura, and lung of normal rabbits.正常兔血清、胸水、胸膜及肺中头孢拉定的浓度。
J Antimicrob Chemother. 1981 Oct;8(4):345-6. doi: 10.1093/jac/8.4.345.
3
Cefazolin and cephradine: relationship between serum concentrations and tissue contents in mice.头孢唑林和头孢拉定：小鼠血清浓度与组织含量之间的关系
Infection. 1978;6(4):166-70. doi: 10.1007/BF01641906.
4
Tissue levels of cephradine in ischaemic limbs following a single intravenous injection.单次静脉注射后缺血肢体中的头孢拉定组织水平。
Curr Med Res Opin. 1980;6(9):585-8. doi: 10.1185/03007998009109492.
5
Cephradine (Velosef) penetration of mandibular bone.头孢拉定（先锋霉素Ⅵ）在下颌骨中的渗透情况。
Int J Oral Maxillofac Surg. 1990 Apr;19(2):120-1. doi: 10.1016/s0901-5027(05)80208-5.
6
[Interference of the tissue concentration of antibiotics with a salidiuretic. Behaviour of cephradine and cephalothin in brain tissue after additional administration of furosemide (author's transl)].
Klin Wochenschr. 1978 Mar 1;56(5):247-51. doi: 10.1007/BF01477832.
7
[Concentrations of cefradine in renal tissue (author's transl)].
MMW Munch Med Wochenschr. 1979 Oct 19;121(42):1367-9.
8
HPLC analysis of cephradine in human serum and urine.头孢拉定在人血清和尿液中的高效液相色谱分析。
J Clin Hosp Pharm. 1983 Dec;8(4):373-4. doi: 10.1111/j.1365-2710.1983.tb01061.x.
9
Qualitative and quantitative analysis of cephradine in biological materials by high performance liquid chromatography.高效液相色谱法对生物材料中的头孢拉定进行定性和定量分析。
Forensic Sci Int. 1987 Apr;33(4):267-74. doi: 10.1016/0379-0738(87)90108-3.
10
Determination of serum and bone concentrations of cephradine and cefuroxime by HPLC in patients undergoing hip and knee joint replacement surgery.采用高效液相色谱法测定髋关节和膝关节置换手术患者血清及骨中头孢拉定和头孢呋辛的浓度。
J Antimicrob Chemother. 1989 Jun;23(6):877-83. doi: 10.1093/jac/23.6.877.
引用本文的文献
1
Beta-lactam combination treatment overcomes rifampicin resistance in Mycobacterium tuberculosis.β-内酰胺联合治疗可克服结核分枝杆菌对利福平的耐药性。
Eur J Clin Microbiol Infect Dis. 2025 May;44(5):1279-1284. doi: 10.1007/s10096-025-05062-3. Epub 2025 Mar 6.
2
Pulmonary disposition of antimicrobial agents: methodological considerations.
Antimicrob Agents Chemother. 1992 Jun;36(6):1171-5. doi: 10.1128/AAC.36.6.1171.
本文引用的文献
1
[Experimental studies on cephaloridin].
Orv Hetil. 1966 Nov 27;107(48):2264-8.
2
[Detemination of cephalexin in serum, urine, bile, peritoneal exudate and bone marrow].
Dtsch Med Wochenschr. 1971 Mar 12;96(11):464-8. doi: 10.1055/s-0028-1108274.
3
Antibiotic concentrations in septic joint effusions.
N Engl J Med. 1971 Feb 18;284(7):349-53. doi: 10.1056/NEJM197102182840702.
4
Cephalexin--a new oral antibiotic.
Practitioner. 1970 Dec;205(230):791-5.
5
Clinical evaluation of cephaloglycin in the treatment of urinary tract infections.头孢甘氨酸治疗尿路感染的临床评估。
Chemotherapia (Basel). 1968;13(4):193-203. doi: 10.1159/000220549.
6
Cephradine. Antibacterial activity and clinical effectiveness.
Chemotherapy. 1973;18(3):191-204. doi: 10.1159/000221261.
7
Tissue distribution of cephalexin in pregnant rabbit and fetus after oral and intramuscular administration.
Chemotherapy. 1972;17(5):344-7. doi: 10.1159/000220866.
8
Cephradine absorption and excretion in fasting and nonfasting volunteers.
J Clin Pharmacol New Drugs. 1973 Jan;13(1):36-40. doi: 10.1002/j.1552-4604.1973.tb00066.x.
9
The use of oral penicillins and cephalosporins in the treatment of urinary tract infections.
Int J Clin Pharmacol. 1972 Apr;6(1):1-6.
10
[Methicillin concentration in serum and lung tissue in man].
Acta Chir Acad Sci Hung. 1974;15(4):375-82.
Zotero 插件