Ishii H, Arai T, Morikawa S, Inubushi T, Tooyama I, Kimura H, Mori K
Department of Anesthesia, Kyoto University Hospital, Japan.
J Cereb Blood Flow Metab. 1998 Sep;18(9):931-4. doi: 10.1097/00004647-199809000-00001.
Correlation of focal ischemia-induced brain damage evidenced by magnetic resonance imaging (MRI) and by staining with microtubule-associated protein 2 (MAP2) was studied in rats. Ischemia was produced by transient occlusion of the middle cerebral artery (MCAO). The damage was assessed at 6 to 8 hours after MCAO and 1 week later. The area of damage assessed by MRI agreed with that by MAP2 staining at 6 to 8 hours after MCAO, which was smaller (P < 0.001) than that defined by MAP2 staining 1 week after MCAO. Glial staining indicated that glial infiltration affected the signal intensity of MRI in the area of damage.
在大鼠中研究了通过磁共振成像（MRI）和微管相关蛋白2（MAP2）染色所证实的局灶性缺血性脑损伤的相关性。通过大脑中动脉短暂闭塞（MCAO）产生缺血。在MCAO后6至8小时和1周后评估损伤情况。MRI评估的损伤面积在MCAO后6至8小时与MAP2染色评估的面积一致，且该面积比MCAO后1周MAP2染色所确定的面积小（P<0.001）。胶质细胞染色表明胶质细胞浸润影响了损伤区域MRI的信号强度。
