Markowitz G S, Stemmer C L, Croker B P, D'Agati V D
Department of Pathology, Columbia Presbyterian Medical Center, New York, NY 10032, USA.
Am J Kidney Dis. 1998 Sep;32(3):508-13. doi: 10.1053/ajkd.1998.v32.pm9740171.
Beyond the acute posttransplantation period, glomerular causes of proteinuria in the renal allograft include recurrent glomerulopathy, transplant-associated entities, and de novo disease. We present a case of de novo minimal change disease with reversible acute renal failure occurring 2.5 years posttransplantation in a 56-year-old man. The cause of end-stage renal disease in the native kidney was membranous glomerulopathy. De novo minimal change disease in the renal allograft is an extremely rare entity requiring stringent clinical-pathological criteria for diagnosis. Many of the cases previously reported as de novo minimal change disease fail to meet these criteria. We review the eight reported cases that appear to fulfill a strict definition of minimal change disease in the context of the current report.
在移植后的急性期过后，肾移植受者蛋白尿的肾小球病因包括复发性肾小球病、移植相关疾病和新发疾病。我们报告一例56岁男性患者，在肾移植2.5年后发生新发微小病变病并伴有可逆性急性肾衰竭。其原肾终末期肾病的病因是膜性肾小球病。肾移植受者新发微小病变病是一种极其罕见的疾病，诊断需要严格的临床病理标准。许多先前报告为新发微小病变病的病例并不符合这些标准。我们结合本报告回顾了八例似乎符合微小病变病严格定义的病例。
