Giannattasio C, Failla M, Grappiolo A, Bigoni M, Carugo S, Denti M, Mancia G
From the Cattedre di Medicina Interna and Ortopedia , Università di Milano and Ospedale S. Gerardo, Monza; and the Centro di Fisiologia Clinica e Ipertensione, IRCSS Ospedale Maggiore, Milano (G.M.), Italy.
Hypertension. 1998 Sep;32(3):584-7. doi: 10.1161/01.hyp.32.3.584.
Physical training is associated with an increase in arterial distensibility. Whether the effect of training on this variable is evident also for ordinary levels of exercise or no exercise is unknown, however. We have addressed this issue by investigating the effect on radial artery distensibility of prolonged monolateral immobilization of the ipsilateral limb versus the following resumption of normal mobility. We studied 7 normotensive subjects (age, 25.4+/-3.0 years; systolic/diastolic blood pressure, 119+/-9/68+/-6 mm Hg, mean+/-SE) in whom 1 limb had been immobilized for 30 days in plaster because of a fracture of the elbow. At both the day after plaster removal and after 45 days of rehabilitation, radial artery distensibility was evaluated by an echo-tracking device (NIUS-02), which allows arterial diameter to be measured noninvasively and continuously over all pressures from diastole to systole (finger monitoring), with the distensibility values being continuously derived from the Langewouters formula. In both instances, the contralateral arm was used as control. Immediately after removal of the plaster, radial artery distensibility was markedly less in the previously immobilized and fractured limb compared with the contralateral limb (0.4+/-0.1 versus 0.8+/-0.1, 1/mm Hg 10(-3), P<0.05). After rehabilitation, the distensibility of the radial artery was markedly increased in the previously fractured limb (0.65+/-0.1 1/mm Hg 10(-3), P<0.05), whereas no change was seen in the contralateral limb. Thus, complete interruption of physical activity is associated with a marked reduction of arterial distensibility, indicating that even an ordinary level of activity plays a major role in modulation of arterial mechanical properties.
体育锻炼与动脉扩张性增加有关。然而，对于普通运动水平或不运动而言，训练对这一变量的影响是否明显尚不清楚。我们通过研究同侧肢体长时间单侧固定后恢复正常活动对桡动脉扩张性的影响来解决这个问题。我们研究了7名血压正常的受试者（年龄25.4±3.0岁；收缩压/舒张压为119±9/68±6 mmHg，均值±标准误），他们因肘部骨折而用石膏固定1条肢体30天。在拆除石膏后的当天以及康复45天后，用回声跟踪装置（NIUS - 02）评估桡动脉扩张性，该装置可在从舒张期到收缩期的所有压力下无创且连续地测量动脉直径（手指监测），并根据Langewouters公式连续得出扩张性值。在这两种情况下，对侧手臂用作对照。拆除石膏后，与对侧肢体相比，先前固定和骨折肢体的桡动脉扩张性明显降低（0.4±0.1对0.8±0.1，1/mm Hg 10⁻³，P<0.05）。康复后，先前骨折肢体的桡动脉扩张性明显增加（0.65±0.1 1/mm Hg 10⁻³，P<0.05），而对侧肢体未见变化。因此，身体活动的完全中断与动脉扩张性的显著降低有关，这表明即使是普通水平的活动在调节动脉力学特性方面也起主要作用。
