Ersöz C, Cetik F, Aydin O, Cosar E F, Talas D U
Department of Pathology, Medical Faculty, Cukurova University, Adana, Turkey.
Diagn Cytopathol. 1998 Sep;19(3):201-4. doi: 10.1002/(sici)1097-0339(199809)19:3<201::aid-dc10>3.0.co;2-i.
Salivary duct carcinoma (SDC) is an uncommon and highly aggressive neoplasm that reveals histopathologic features resembling infiltrating duct carcinoma of the breast and prostate. SDC arising on the basis of preexisting pleomorphic adenoma (PA) is very rare. This report describes the fine-needle aspiration (FNA) cytology of a case of SDC ex PA. FNA smears were cellular with cells with large, pleomorphic nuclei, some prominent nucleoli, and finely vacuolated cytoplasm. The neoplastic cells were forming groups, sheets, and papillary structures and a cribriform pattern was present in some sheets. Mitotic figures were frequently seen. Necrosis was prominent in the background. Histologic sections of the tumor revealed areas of comedo carcinoma, papillary carcinoma, and infiltrative carcinoma as well as multiple foci of PA. The presence of a cribriform pattern, tumor cells resembling breast ductal carcinoma cells, and a necrotic background are helpful features for an accurate cytodiagnosis of SDC.
涎腺导管癌（SDC）是一种罕见且侵袭性很强的肿瘤，其组织病理学特征类似于乳腺和前列腺的浸润性导管癌。在先前存在的多形性腺瘤（PA）基础上发生的SDC非常罕见。本报告描述了一例PA基础上发生的SDC的细针穿刺（FNA）细胞学表现。FNA涂片细胞丰富，细胞具有大的、多形性核，一些核仁突出，胞质呈细空泡状。肿瘤细胞形成团块、片状和乳头状结构，一些片状区域可见筛状结构。常见有丝分裂象。背景中坏死明显。肿瘤的组织学切片显示粉刺癌、乳头状癌和浸润性癌区域以及多个PA灶。筛状结构、类似乳腺导管癌细胞的肿瘤细胞以及坏死背景的存在有助于对SDC进行准确的细胞诊断。
