Yoshihara T, Tanaka M, Itoh M, Ishii T
Department of Otolaryngology, Tokyo Women's Medical College, Japan.
J Laryngol Otol. 1995 Mar;109(3):240-3. doi: 10.1017/s0022215100129809.
A case of carcinoma ex pleomorphic adenoma arising in the soft palate is reported. The tumour presented had enlarged gradually over 10 years and finally occupied the oral cavity. The patient was admitted to our hospital due to disturbance of her speech and swallowing, and a sudden haemorrhage from the tumour. The initial pathological diagnosis by open biopsy was benign pleomorphic adenoma. After total resection, histological examination revealed that the tumour was composed partly of benign pleomorphic adenoma and partly of an adenocarcinomatous component. The carcinoma cells with prominent nucleoli were spheroid or polygonal in shape, and frequently formed ductal structures with areas of necrosis. Mitoses were also found. These findings showed that this tumour was a secondary carcinoma which had developed in a preexisting pleomorphic adenoma.
本文报告1例起源于软腭的多形性腺瘤恶变病例。该肿瘤在10年间逐渐增大，最终占据口腔。患者因言语及吞咽障碍、肿瘤突然出血而入院。开放活检的初始病理诊断为良性多形性腺瘤。全切除术后，组织学检查显示肿瘤部分由良性多形性腺瘤构成，部分由腺癌成分构成。癌细胞核仁显著，呈球形或多边形，常形成有坏死区域的导管结构，也可见核分裂象。这些发现表明该肿瘤是在原有多形性腺瘤基础上发生的继发性癌。
