Kaskel F J, Kleinman L I
Biol Neonate. 1976;29(5-6):306-14. doi: 10.1159/000240880.
In piglets 14-40 days of age, blood pressure and glomerular filtration rate increased significantly with age and were lower than those reported for adult pigs. There was no effect of dietary salt on the maturation of these parameters and on tubular sodium reabsorption, although the piglets on a low salt diet had lower inulin space than piglets receiving higher dietary salt. After the completion of a 24-hour salt challenge there was little evidence of sodium retention and there was no effect of previous dietary salt intake on sodium excretion. However, salt challenge resulted in higher blood pressure and elevated serum sodium only in piglets on a low sodium diet. These results suggest that in contrast to puppies and infants, the renal response to salt challenge is physiologically adequate in piglets at 14-40 days although glomerular function is still immature. Dietary salt history appears to have little effect on the degree of sodium excretion during salt challenge in this age range.
在14至40日龄的仔猪中，血压和肾小球滤过率随年龄显著增加，且低于成年猪的报道值。日粮盐分对这些参数的成熟以及肾小管钠重吸收没有影响，尽管低盐日粮仔猪的菊粉空间低于接受较高日粮盐分的仔猪。在24小时盐分挑战结束后，几乎没有钠潴留的证据，且先前的日粮盐分摄入量对钠排泄没有影响。然而，盐分挑战仅在低钠日粮仔猪中导致血压升高和血清钠升高。这些结果表明，与幼犬和婴儿不同，14至40日龄仔猪对盐分挑战的肾脏反应在生理上是足够的，尽管肾小球功能仍不成熟。在这个年龄范围内，日粮盐分历史似乎对盐分挑战期间的钠排泄程度影响很小。
