Gök S, Ulker S, Evinç A
Department of Pharmacology, School of Medicine, Celal Bayar University, Manisa, Turkey.
Pharmacology. 1998 Nov;57(5):279-84. doi: 10.1159/000028252.
The effect of a leukotriene D4 (LTD4) receptor antagonist, L-648,051, was investigated in digoxin-induced cardiac toxicity in isolated guinea-pig hearts (Langendorff preparation). Digoxin infusion (25 microg.ml-1, 0.5 ml.min-1) increased perfusion pressure and contractile force initially, but decreased them later. The onset of first ventricular premature beats (VPBs) matched the increase phase, but the decrease phase was accompanied by ventricular tachycardia (VT) and fibrillation (VF). In the presence of L-648,051 (5 micromol. l-1), the initial phase was similar to that observed with digoxin alone, but the marked reduction was inhibited. This drug increased the concentration of digoxin required for VBSs and cardiac arrest, but it could not prevent the formation of VT and VF. The duration of VT was significantly decreased by L-648,051. It is concluded that the leukotriene receptor antagonist might have beneficial effects on digoxin-induced arrhythmias. Whether this effect depends on direct or indirect actions is uncertain.
在离体豚鼠心脏（Langendorff 制备）中，研究了白三烯 D4（LTD4）受体拮抗剂 L-648,051 对洋地黄诱导的心脏毒性的影响。输注洋地黄（25 微克·毫升⁻¹，0.5 毫升·分钟⁻¹）最初会增加灌注压和收缩力，但随后会使其降低。首次室性早搏（VPB）的出现与增加期相符，但降低期伴有室性心动过速（VT）和颤动（VF）。在存在 L-648,051（5 微摩尔·升⁻¹）的情况下，初始阶段与单独使用洋地黄时观察到的相似，但显著降低受到抑制。该药物增加了发生 VBS 和心脏骤停所需的洋地黄浓度，但无法预防 VT 和 VF 的形成。L-648,051 显著缩短了 VT 的持续时间。结论是白三烯受体拮抗剂可能对洋地黄诱导的心律失常有有益作用。这种作用是否取决于直接或间接作用尚不确定。
