Neuberger J
Liver Unit, Queen Elizabeth Hospital, Birmingham, England.
Liver Transpl Surg. 1998 Sep;4(5 Suppl 1):S51-7.
It is now accepted that patients who receive a liver transplant for alcohol-related liver disease have a rate of survival similar to those who receive grafts for other indications. Abstinence from alcohol before liver transplantation is important in ensuring that the liver will not recover, but the period of abstinence required before transplantation is undertaken is uncertain. Prognostic models for assessing patients with alcoholic liver disease have been developed but correlate poorly with each other. A return to alcohol consumption after transplantation is not uncommon, although graft failure or damage is uncommon. However, alcohol-related liver disease is becoming an increasing indication for liver transplantation. As the number of potential candidates exceeds the supply of donors, some form of rationing will be required. The general public places a lower priority on transplantation for alcoholic liver disease than for other indications, and this will need to be considered by those who allocate the donor livers.
目前已公认,因酒精性肝病接受肝移植的患者的生存率与因其他适应症接受移植的患者相似。肝移植前戒酒对于确保肝脏不会恢复很重要,但移植前所需的戒酒时间尚不确定。已经开发了用于评估酒精性肝病患者的预后模型,但这些模型之间的相关性很差。移植后恢复饮酒的情况并不少见,尽管移植失败或受损的情况并不常见。然而,酒精性肝病正成为肝移植越来越常见的适应症。由于潜在候选者的数量超过了供体的供应,将需要某种形式的配给。普通公众对酒精性肝病移植的重视程度低于其他适应症,负责分配供体肝脏的人员需要考虑这一点。