Neuberger James
Liver Unit, Queen Elizabeth Hospital, Birmingham, UK.
Liver Transpl. 2007 Nov;13(11 Suppl 2):S65-8. doi: 10.1002/lt.21337.
The discrepancy between the number of people who might benefit from liver transplantation continues to exceed the availability of donor livers available, so rationing of grafts must occur. Alcoholic liver disease (ALD) is an excellent indication for liver transplantation, with outcomes at least as good as for other indications.ALD remains a controversial indication for liver transplantation. There is no robust evidence that public disquiet over distribution of donor livers to those with ALD (even if they return to alcohol) greatly affects organ donation, although this does not mean there is no consequence of such disquiet. Numerous surveys of the general public, patients, and health care professionals indicate the these patients are thought to have lower priority for access to available liver grafts. Public education is required to demonstrate that patients with ALD are carefully selected for liver transplantation and available grafts are used with attention to equity, justice, and utility.
可能从肝移植中获益的人数与可用供体肝脏数量之间的差距持续存在,且供体肝脏供不应求,因此必须对肝脏移植进行分配。酒精性肝病(ALD)是肝移植的理想适应症,其治疗效果至少与其他适应症相同。然而,ALD仍是肝移植领域一个颇具争议的适应症。目前尚无确凿证据表明公众对将供体肝脏分配给ALD患者(即使他们再次酗酒)的担忧会对器官捐献产生重大影响,尽管这并不意味着这种担忧没有后果。针对普通公众、患者和医护人员的多项调查表明,这些患者在获取可用肝脏移植方面被认为优先级较低。需要开展公众教育,以证明ALD患者在接受肝移植时经过了严格筛选,并且在分配可用肝脏时会兼顾公平、公正和效用原则。