在大鼠中，GalR2甘丙肽受体介导甘丙肽诱导的空肠收缩，但不介导进食行为：受体亚型激活的中枢和外周效应的分化。

The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.

作者信息

Wang S, Ghibaudi L, Hashemi T, He C, Strader C, Bayne M, Davis H, Hwa J J

机构信息

Department of CNS/CV Biological Research, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.

出版信息

FEBS Lett. 1998 Sep 4;434(3):277-82. doi: 10.1016/s0014-5793(98)00957-0.

DOI:10.1016/s0014-5793(98)00957-0

PMID:9742938

Abstract

The neuropeptide galanin mediates a diverse array of physiological functions through activation of specific receptors. Roles of the three recently cloned galanin receptors (GalRs) in rat intestinal contraction and food intake were examined using GalR-selective ligands and the results were compared with the pharmacological profiles of defined GalRs. The action profile of these ligands in jejunal contraction resembled only that of GalR2 and only a high level of GalR2 mRNA was detected in the tissue, supporting GalR2 as the receptor mediating jejunal contraction. The action profile for food intake in rats excluded GalR2, GalR3 and the putative pituitary galanin receptor as the 'feeding receptor', suggesting that either GalR1 or an unidentified GalR is responsible for mediating this function.

摘要

神经肽甘丙肽通过激活特定受体介导多种生理功能。使用甘丙肽受体（GalRs）选择性配体研究了最近克隆的三种甘丙肽受体在大鼠肠道收缩和食物摄入中的作用，并将结果与已明确的甘丙肽受体的药理学特征进行了比较。这些配体在空肠收缩中的作用谱仅与甘丙肽受体2（GalR2）相似，并且在该组织中仅检测到高水平的GalR2信使核糖核酸（mRNA），这支持GalR2作为介导空肠收缩的受体。大鼠食物摄入的作用谱排除了GalR2、GalR3和假定的垂体甘丙肽受体作为“进食受体”，这表明要么是GalR1要么是一种未确定的甘丙肽受体负责介导该功能。