Marin R, McMillian D
South Med J. 1998 Sep;91(9):875-8. doi: 10.1097/00007611-199809000-00017.
Side effects are a common occurrence in the use of subdermal contraceptive implants (Norplant); approximately 70% to 80% of women using the device report abnormal uterine bleeding, headaches, acne, mastalgia, nervousness, appetite changes, and weight gain. Local implant site reactions range from 0.4% to 4.7%, with pain being the most common. Other insertion site complications include infection and implant expulsion. Only three cases have been described in the literature concerning implant site-related neuropathy, involving the sensory branch of the musculocutaneous nerve (lateral cutaneous nerve) in two cases and the antebrachial cutaneous nerve in the third case. We believe our report is the first case of an axonal loosing motor and sensory ulnar neuropathy associated with the removal of a subdermal contraceptive implant (Norplant). We review insertion site complications and their most likely causes. Also, we discuss alternative removal techniques for difficult-to-remove implants.
副作用是皮下避孕植入剂（诺普兰）使用过程中的常见现象；使用该装置的女性中约70%至80%报告有异常子宫出血、头痛、痤疮、乳房疼痛、紧张、食欲改变和体重增加。局部植入部位反应发生率为0.4%至4.7%，疼痛最为常见。其他插入部位并发症包括感染和植入物排出。文献中仅描述了3例与植入部位相关的神经病变，其中2例累及肌皮神经（外侧皮神经）的感觉支，第3例累及前臂内侧皮神经。我们认为我们的报告是首例与皮下避孕植入剂（诺普兰）取出相关的轴索性运动和感觉性尺神经病变。我们回顾了插入部位并发症及其最可能的原因。此外，我们还讨论了难以取出的植入物的替代取出技术。
