Blake D W, Hogg M N, Hackman C H, Pang J, Bjorksten A R
Royal Melbourne Hospital, Victoria, Australia.
Anaesth Intensive Care. 1998 Aug;26(4):360-5. doi: 10.1177/0310057X9802600403.
Inhalation induction with sevoflurane was compared with propofol or sevoflurane/propofol in 60 unpremedicated adults. Target concentrations for the three groups (with 60% nitrous oxide) were 3% end-tidal sevoflurane, 12 mg/l propofol and 1.5% sevoflurane/6 mg/l propofol respectively, prior to insertion of a laryngeal mask airway (LMA) at 10 minutes. Induction of anaesthesia was satisfactory in each group, but movement response to LMA insertion was observed in 20 patients (least in the sevoflurane group). Cardiovascular responses were similar except for a lower heart rate in the sevoflurane group. EEG bispectral index suggested a greater depth of anaesthesia in the inhalation induction group. A bispectral index of 60 separated patients responding to LMA insertion from nonresponders (P = 0.006), and had a sensitivity of 68% and specificity 70%. Movement response was not predicted by cardiovascular changes.
在60例未使用术前药的成年患者中，比较了七氟醚吸入诱导与丙泊酚或七氟醚/丙泊酚诱导的效果。三组（使用60%氧化亚氮）在插入喉罩气道（LMA）前10分钟的目标浓度分别为：呼气末七氟醚3%、丙泊酚12mg/L以及七氟醚1.5%/丙泊酚6mg/L。每组麻醉诱导均令人满意，但20例患者在插入LMA时出现了运动反应（七氟醚组最少）。除七氟醚组心率较低外，心血管反应相似。脑电图双谱指数表明吸入诱导组麻醉深度更深。双谱指数为60时，可将对插入LMA有反应的患者与无反应者区分开（P = 0.006），其敏感性为68%，特异性为70%。心血管变化无法预测运动反应。
