结直肠扁平隆起型肿瘤的边缘不规则作为恶性潜能的标志物
Marginal irregularity of flat elevated type of colorectal tumor as a marker of malignant potential.
作者信息
Imai Y, Terai T, Miwa H, Ohno Y, Ogihara T, Sato N
机构信息
Department of Gastroenterology, Juntendo University, School of Medicine, Tokyo, Japan.
出版信息
Gastrointest Endosc. 1998 Sep;48(3):263-6. doi: 10.1016/s0016-5107(98)70188-9.
BACKGROUND
The malignant potential of superficial elevated type tumors is still controversial. Because biopsy specimens alone are sometimes not sufficient for diagnosis due to histologic heterogeneity within the tumor, other clinical parameters for evaluation of the degree of malignancy would be helpful.
METHODS
A new morphometric parameter, the "F-circle," which represents the irregularity of the tumor margin, was studied in 115 endoscopically recognized superficial, flat, elevated type colorectal tumors without a central depressed area with respect to histologic evaluation of the degree of malignancy.
RESULTS
The mean F-circle values of adenomatous lesions with mild or moderate atypia, severe atypia, and adenocarcinoma were 0.709+/-0.115, 0.619+/-0.149, and 0.536+/-0.133, respectively.
CONCLUSION
The superficial elevated type of colorectal tumor having more marginal irregularity had a greater malignant potential, and the F-circle may be a useful clinical parameter for evaluation of the degree of malignancy.
背景
浅表隆起型肿瘤的恶性潜能仍存在争议。由于肿瘤内部组织学异质性，仅靠活检标本有时不足以进行诊断，因此其他评估恶性程度的临床参数会有所帮助。
方法
研究了一个新的形态测量参数“F 环”，它代表肿瘤边缘的不规则性，该参数在 115 例经内镜识别的无中央凹陷区的浅表、扁平、隆起型结直肠肿瘤中用于组织学评估恶性程度。
结果
轻度或中度异型增生、重度异型增生及腺癌的腺瘤性病变的平均 F 环值分别为 0.709±0.115、0.619±0.149 和 0.536±0.133。
结论
边缘不规则性更高的浅表隆起型结直肠肿瘤具有更大的恶性潜能，F 环可能是评估恶性程度的一个有用的临床参数。
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