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[抗凝血酶III在子痫前期-子痫中的作用。初步研究]

[Antithrombin-III in preeclampsia-eclampsia. Pilot study].

作者信息

Verduzco Rodríguez L, González Puebla E, López Ariza B, Manffrini Madrid F

机构信息

Hospital Regional de Río Blanco, Veracruz.

出版信息

Ginecol Obstet Mex. 1998 Aug;66:343-6.

PMID:9745197
Abstract

The functional levels of AT-III were determined to the following groups: A. Eleven healthy non pregnant women B. Thirteen healthy pregnant women (third trimester). C. Six preeclamptic patients. D. Five patients with eclampsia and/or HELP syndrome. The results were as follows: [table: see text] A different grade of DIC may explain the low activity of AT-III in preeclampsia and a more severe coagulation disorder in eclampsia and HELP syndrome. Our preliminary results encourage other prospective studies including larger populations to determine its usefulness as early diagnostic test and severity marker of the disease.

摘要

测定了以下几组人群的抗凝血酶III(AT-III)功能水平:A组. 11名健康未孕女性;B组. 13名健康孕妇(孕晚期);C组. 6名先兆子痫患者;D组. 5名子痫和/或HELLP综合征患者。结果如下:[表格:见正文]不同程度的弥散性血管内凝血(DIC)可能解释了先兆子痫中AT-III活性降低以及子痫和HELLP综合征中更严重的凝血障碍。我们的初步结果鼓励开展其他前瞻性研究,纳入更多人群,以确定其作为该疾病早期诊断测试和严重程度标志物的效用。

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