孕早期联合使用孕妇血清妊娠相关血浆蛋白A和游离β-人绒毛膜促性腺激素以及胎儿颈部透明带厚度进行唐氏综合征筛查。
First trimester screening for Down's syndrome using maternal serum PAPP-A and free beta-hCG in combination with fetal nuchal translucency thickness.
作者信息
Biagiotti R, Brizzi L, Periti E, d'Agata A, Vanzi E, Cariati E
机构信息
Department of Obstetrics and Gynaecology, University of Florence, Italy.
出版信息
Br J Obstet Gynaecol. 1998 Aug;105(8):917-20. doi: 10.1111/j.1471-0528.1998.tb10239.x.
The aim of this study was to evaluate the potential effectiveness of maternal serum pregnancy-associated plasma protein A (PAPP-A) and free beta-hCG in combination with nuchal translucency thickness in first trimester screening for Down's syndrome. Maternal serum levels of PAPP-A and free beta-hCG were assayed in stored sera from 32 Down's syndrome and 200 unaffected pregnancies. Fetal nuchal translucency was measured by ultrasound at the time of blood sampling. Screening of Down's syndrome using a combination of maternal age, PAPP-A, free beta-hCG and nuchal translucency would achieve a detection rate of 75.8% for a false positive rate of 5%.
本研究的目的是评估孕早期联合检测孕妇血清妊娠相关血浆蛋白A（PAPP-A）、游离β-人绒毛膜促性腺激素（β-hCG）与颈部透明带厚度用于唐氏综合征筛查的潜在有效性。检测了32例唐氏综合征妊娠和200例正常妊娠的储存血清中PAPP-A和游离β-hCG的母体血清水平。在采血时通过超声测量胎儿颈部透明带厚度。联合孕妇年龄、PAPP-A、游离β-hCG和颈部透明带厚度进行唐氏综合征筛查，在假阳性率为5%时，检出率可达75.8%。
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