Pollok J M, Ibarra C, Broelsch C E, Vacanti J P
Department of Surgery, Children's Hospital, Harvard Medical School, Boston, MA, USA.
Zentralbl Chir. 1998;123(7):830-3.
Islet transplantation is a potential cure for diabetes mellitus. The major problem for clinical application remains the prevention of transplant rejection without major side effects. Broad application in early disease will make the usage of xenogeneic tissue necessary. Immunoisolation is an experimental strategy to prevent rejection, by separating the transplanted allogeneic or xenogeneic cells from the host immune system using a barrier device. Current methods of immunoisolation use artificial, not completely inert materials as barrier devices and induce an unwanted foreign body reaction. Using recipient own cells for encapsulation the foreign body reaction could be prevented. This study describes a new method of encapsulation of islets of Langerhans within a capsule of chondrocytes, which may serve as an immunoisolation barrier utilizing the immunoprivileged properties of the chondrocyte matrix and demonstrates the functional survival of the encapsulated islets in vivo.
胰岛移植是糖尿病的一种潜在治疗方法。临床应用的主要问题仍然是在没有重大副作用的情况下预防移植排斥反应。在疾病早期广泛应用将使异种组织的使用成为必要。免疫隔离是一种预防排斥反应的实验策略，通过使用屏障装置将移植的同种异体或异种细胞与宿主免疫系统分离。目前的免疫隔离方法使用人工的、并非完全惰性的材料作为屏障装置，并引发不必要的异物反应。使用受体自身细胞进行包封可以预防异物反应。本研究描述了一种将胰岛包裹在软骨细胞胶囊内的新方法，该方法可利用软骨细胞基质的免疫赦免特性作为免疫隔离屏障，并证明了包封胰岛在体内的功能存活。
