类人猿Y染色体的分子系统发育学
Molecular phylogenetics of the hominoid Y chromosome.
作者信息
Samonte R V, Conte R A, Verma R S
机构信息
Division of Genetics, The Long Island College Hospital--SUNY Health Science Center, Brooklyn 11201-5514, USA.
出版信息
J Hum Genet. 1998;43(3):185-6. doi: 10.1007/s100380050066.
The Human Y-chromosome plays a central role in sex determination, and is composed of DNA sequences homologous to the Y-chromosome, families of Y-specific repetitive DNA sequences, and single copy sequences. We investigated the chromosomal location of Y-specific DNA sequences, in the chimpanzee (Pan troglodytes), gorilla (Gorilla gorilla), and orangutan (Pongo pygmaeus) by the fluorescence in situ hybridization (FISH) technique. The Yq subtelomeric DNA sequences (DYS427) have been observed to be intact at the presumed loci. Also, the amelogenin gene (AMELY, Yp11.2) revealed sequence homology and positional conservation in the higher primates, except in gorilla where positional divergence was observed.
人类Y染色体在性别决定中起核心作用，由与Y染色体同源的DNA序列、Y特异性重复DNA序列家族和单拷贝序列组成。我们通过荧光原位杂交（FISH）技术研究了黑猩猩（Pan troglodytes）、大猩猩（Gorilla gorilla）和猩猩（Pongo pygmaeus）中Y特异性DNA序列的染色体定位。已观察到Yq亚端粒DNA序列（DYS427）在假定位点处是完整的。此外，牙釉蛋白基因（AMELY，Yp11.2）在高等灵长类动物中显示出序列同源性和位置保守性，但在大猩猩中观察到位置差异。
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