Laba E, Dumitrescu G, Ardeleanu C, Gogălniceanu D, Laba C D
Departament of Pathology, University of Medicine and Pharmacy Gr. T. Popa, Iaşi, Romania.
Rom J Morphol Embryol. 1997 Jul-Dec;43(3-4):205-12.
The "Histological Typing of Odontogenic Tumours" (W.H.O., 1992) classified the Calcifying Odontogenic Cyst (C.O.C.) into two variants: the non-neoplastic cystic C.O.C. and the odontogenic ghost cell tumour, which is predominantly solid. We reported two cases of C.O.C.: a case with intraosseous development and another with extraosseous localisation, in the soft tissue of the alveolar area. The first case represents a cyst delimited by a squamous, non-keratinized epithelium, thickened in some areas through the accumulation of ghost cells (big pale-staining cells with a non-staining nuclear area). The connective tissue wall contains small ameloblastoma like islands. Dysplastic dentine islands, adjacente to the basal layer of the epithelium or in the connective tissue wall were also observed. The second case was a well-delimitated tumour consisting of ameloblastoma-like islands with numerous ghost cells inside. Islands of dysplastic dentine with psammomathous calcifications also exist. In certain histological sections microcystic aspects surrounded by ghost cells, dentinoid and ameloblastoma-like structures were noticed. The histochemical reaction for keratin and the immunohistochemical reaction for epithelial membrane antigen and for citokeratin were positive for ghost cells, suggesting their epithelial origin. Through this article we try to render pathologists sensitive with a particular and rare maxillary tumour.
《牙源性肿瘤的组织学分类》（世界卫生组织，1992年）将牙源性钙化囊肿（C.O.C.）分为两种类型：非肿瘤性囊性牙源性钙化囊肿和牙源性影细胞瘤，后者主要为实性。我们报告了两例牙源性钙化囊肿：一例发生于骨内，另一例位于牙槽区软组织，为骨外定位。第一例为一个囊肿，由鳞状非角化上皮界定，在某些区域因影细胞（大的淡染细胞，核区不着色）的积聚而增厚。结缔组织壁内含有小的成釉细胞瘤样岛。还观察到发育异常的牙本质岛，紧邻上皮基底层或位于结缔组织壁内。第二例是一个界限清楚的肿瘤，由成釉细胞瘤样岛组成，内部有许多影细胞。也存在有砂粒体样钙化的发育异常牙本质岛。在某些组织学切片中，可见影细胞、类牙本质和类似成釉细胞瘤结构所围绕的微囊样区域。影细胞对角蛋白的组织化学反应以及对上皮膜抗原和细胞角蛋白的免疫组织化学反应均为阳性，提示其上皮来源。通过本文，我们试图让病理学家对一种特殊且罕见的上颌肿瘤有所认识。
