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[卡马西平所致皮肤假性淋巴瘤]

[Cutaneous pseudolymphoma caused by carbamazepine].

作者信息

d'Incan M, Mouillet M L, Roger H, Ferrier M C, Buono J P, Déchelotte P, Bignon Y J, Souteyrand P

机构信息

Service de Dermatologie-Vénéréologie, Hôtel-Dieu, Clermont-Ferrand.

出版信息

Ann Dermatol Venereol. 1998 Jan;125(1):52-5.

PMID:9747211
Abstract

INTRODUCTION

Drug-induced cutaneous pseudolymphomas are poorly reported. They clinically and pathologically mimic malignant lymphomas but their evolution is benign after drug withdrawal.

CASE REPORT

We herein reported a case of carbamazepine++-induced pseudolymphoma in a 30 year-old woman of particular interest because of the paucity of clinical symptoms (only six papules of less than one centimetre each).

COMMENTS

Phenytoins, carbamazepine++, barbiturates and ACE inhibitors are the main drugs inducing cutaneous pseudolymphomas. These usually mimic T-cell lymphomas. The clinical spectrum of cutaneous pseudolymphomas is broad including severe aspects, such as erythroderma or tumoral eruption and benign appearing one as in our case. Drug investigation is mandatory for each patient with lymphoma appearing cutaneous infiltrates because dramatic and definitive healing of the lesion is always expected in case of pseudolymphoma.

摘要

引言

药物性皮肤假性淋巴瘤的报道较少。它们在临床和病理上模仿恶性淋巴瘤,但停药后病情演变呈良性。

病例报告

我们在此报告一例30岁女性卡马西平诱发的假性淋巴瘤,因其临床症状较少(仅6个直径小于1厘米的丘疹)而备受关注。

评论

苯妥英、卡马西平、巴比妥类药物和血管紧张素转换酶抑制剂是诱发皮肤假性淋巴瘤的主要药物。这些药物通常模仿T细胞淋巴瘤。皮肤假性淋巴瘤的临床谱很广,包括严重的表现,如红皮病或肿瘤性皮疹,以及像我们病例中那样看似良性的表现。对于每一位出现皮肤浸润的淋巴瘤患者,药物调查是必不可少的,因为如果是假性淋巴瘤,总是期望病变能显著且彻底地愈合。

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