[通过尿核磁共振质子光谱法诊断“鱼腥味综合征”]
[Diagnosis of "fish odor syndrome" by urine nuclear magnetic resonance proton spectrometry].
作者信息
Eugène M
机构信息
Laboratoire de RMN, Explorations Fonctionnelles, Hôpital Saint-Louis, Paris.
出版信息
Ann Dermatol Venereol. 1998 Mar;125(3):210-2.
BACKGROUND
Trimethylaminuia is an unusual observation, often termed fish odor syndrome. The condition results from reduced ability to oxidize trimethylamine (TMA), which has a fishy odor, into odorless trimethylamine N-oxide (TMAO).
METHOD
Proton nuclear magnetic resonance spectroscopy (MRS) was used as a simple and rapid method to detect TMA and TMAO in the same urine sample without pretreatment. Subjects were considered to have deficient N-oxidation of TMA if the TMAO/TMA ratio was greater than 80 p. 100 (heterozygous) or 65 p. 100 (homozygous).
DISCUSSION
Direct proton RRS analysis of urine is well suited for diagnosis of fish odor syndrome. It can be used to detect heterozygous patients and also provides an easily implemented follow-up tool.
背景
三甲胺尿症是一种不常见的病症，常被称为鱼腥味综合征。这种病症是由于将有鱼腥味的三甲胺（TMA）氧化为无味的氧化三甲胺（TMAO）的能力降低所致。
方法
质子核磁共振波谱法（MRS）被用作一种简单快速的方法，无需预处理即可在同一尿液样本中检测TMA和TMAO。如果TMAO/TMA比值大于80%（杂合子）或65%（纯合子），则受试者被认为存在TMA氧化不足。
讨论
尿液的直接质子MRS分析非常适合鱼腥味综合征的诊断。它可用于检测杂合子患者，还提供了一种易于实施的随访工具。
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