Alhomida A S
Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Cell Biochem Funct. 1998 Sep;16(3):165-71. doi: 10.1002/(SICI)1099-0844(199809)16:3<165::AID-CBF782>3.0.CO;2-2.
This study is conducted to investigate the effect of oral theophylline administration on total (TC), free (FC), short-(SC), long-chain acyl (LC), acyl (AC) carnitine distributions as well as the ratio of acyl to free carnitine (AC/FC) in rat renal tissues. Theophylline was administrated at 100 mg kg-1 body weight day-1, and effects were monitored after a treatment period that lasted between 1 week and 5 weeks. The results indicated that theophylline administration leads to significantly higher concentrations of TC, FC, SC, L and AC in renal tissues as compared to those of control and placebo groups (P < 0.001). Moreover, the ratio of AC/FC was significantly increased (P < 0.001) as compared to either control or placebo groups. These changes may result from theophylline-enhanced mobilization of lipids from adipose tissues, which consequently stimulates an increased carnitine transport into the renal tissues to form acylcarnitines for subsequent beta-oxidation inside the renal mitochondria.
本研究旨在探讨口服氨茶碱对大鼠肾组织中总肉碱（TC）、游离肉碱（FC）、短链酰基肉碱（SC）、长链酰基肉碱（LC）、酰基肉碱（AC）分布以及酰基与游离肉碱之比（AC/FC）的影响。氨茶碱按100 mg kg-1体重·天-1给药，在持续1周和5周的治疗期后监测效果。结果表明，与对照组和安慰剂组相比，氨茶碱给药导致肾组织中TC、FC、SC、LC和AC的浓度显著升高（P < 0.001）。此外，与对照组或安慰剂组相比，AC/FC之比显著增加（P < 0.001）。这些变化可能是由于氨茶碱增强了脂肪组织中脂质的动员，从而刺激更多的肉碱转运到肾组织中形成酰基肉碱，以便在肾线粒体内进行后续的β氧化。
