Gasparro F P, Mitchnick M, Nash J F
Department of Dermatology & Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Photochem Photobiol. 1998 Sep;68(3):243-56.
The use of sunscreen products has been advocated by many health care practitioners as a means to reduce skin damage produced by ultraviolet radiation (UVR) from sunlight. There is a need to better understand the efficacy and safety of sunscreen products given this ongoing campaign encouraging their use. The approach used to establish sunscreen efficacy, sun protection factor (SPF), is a useful assessment of primarily UVB (290-320 nm) filters. The SPF test, however, does not adequately assess the complete photoprotective profile of sunscreens specifically against long wavelength UVAI (340-400 nm). Moreover, to date, there is no singular, agreed upon method for evaluating UVA efficacy despite the immediate and seemingly urgent consumer need to develop sunscreen products that provide broad-spectrum UVB and UVA photoprotection. With regard to the safety of UVB and UVA filters, the current list of commonly used organic and inorganic sunscreens has favorable toxicological profiles based on acute, subchronic and chronic animal or human studies. Further, in most studies, sunscreens have been shown to prevent the damaging effects of UVR exposure. Thus, based on this review of currently available data, it is concluded that sunscreen ingredients or products do not pose a human health concern. Further, the regular use of appropriate broad-spectrum sunscreen products could have a significant and favorable impact on public health as part of an overall strategy to reduce UVR exposure.
许多医疗保健从业者都提倡使用防晒产品,将其作为减少阳光中紫外线(UVR)对皮肤造成损害的一种手段。鉴于当前鼓励使用防晒产品的宣传活动,有必要更好地了解防晒产品的功效和安全性。用于确定防晒功效的方法——防晒系数(SPF),主要是对UVB(290 - 320纳米)滤光剂的有用评估。然而,SPF测试并不能充分评估防晒霜针对长波长UVA1(340 - 400纳米)的完整光防护特性。此外,尽管消费者迫切需要开发能提供广谱UVB和UVA光防护的防晒产品,但迄今为止,尚无一种统一的、得到认可的评估UVA功效的方法。关于UVB和UVA滤光剂的安全性,根据急性、亚慢性和慢性动物或人体研究,目前常用的有机和无机防晒剂清单具有良好的毒理学特征。此外,在大多数研究中,防晒霜已被证明能预防UVR暴露的有害影响。因此,基于对现有数据的这一综述,得出的结论是防晒成分或产品不会对人类健康构成威胁。此外,作为减少UVR暴露总体战略的一部分,定期使用合适的广谱防晒产品可能会对公众健康产生重大且有益的影响。