猕猴体内SIVmac BK28和H824感染的自然史。
Natural history of SIVmac BK28 and H824 infection in Macaca nemestrina.
作者信息
Mulvania T, Coon E, Kuller L, Agy M B, Morton W R, Mullins J I
机构信息
Department of Microbiology, University of Washington, Seattle 98195-7740, USA.
出版信息
J Med Primatol. 1998 Apr-Jun;27(2-3):87-93. doi: 10.1111/j.1600-0684.1998.tb00231.x.
The natural histories of disease progression induced by two closely related molecular clones of SIVmac were evaluated to determine the utility of these viruses for modeling fast and slow progression to AIDS in Macaca nemestrina. Viral and immune parameters were measured to determine differential progression. Survival time, viral load and CD4+ T cell decline all were indicative of distinct rates of progression, while early measurements of interferon-gamma (IFNgamma) producing cells did not indicate significant differences.
评估了由两种密切相关的SIVmac分子克隆诱导的疾病进展自然史，以确定这些病毒在模拟豚尾猕猴快速和缓慢进展至艾滋病方面的效用。测量病毒和免疫参数以确定不同的进展情况。生存时间、病毒载量和CD4+ T细胞下降均表明进展速度不同，而早期对产生γ干扰素（IFNγ）细胞的测量未显示出显著差异。
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