1型脑铁沉积伴神经变性中的路易小体对α-突触核蛋白呈免疫反应性。
Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for alpha-synuclein.
作者信息
Arawaka S, Saito Y, Murayama S, Mori H
机构信息
Department of Molecular Biology, Tokyo Institute of Psychiatry, Japan.
出版信息
Neurology. 1998 Sep;51(3):887-9. doi: 10.1212/wnl.51.3.887.
In familial PD, a mutation of the alpha-synuclein gene has been identified. Alpha-synuclein also was revealed in Lewy bodies in idiopathic PD. Lewy bodies in neurodegeneration with brain iron accumulation type 1 (NBIA 1; Hallervorden-Spatz syndrome) were found to show immunostaining for alpha-synuclein/precursor of non-A beta component of Alzheimer's disease amyloid, indicating that alpha-synuclein is commonly associated with the formation of Lewy bodies in other sporadic and familial neurodegenerative diseases apart from PD.
在家族性帕金森病中，已鉴定出α-突触核蛋白基因的突变。在特发性帕金森病的路易小体中也发现了α-突触核蛋白。在1型脑铁沉积神经变性（NBIA 1；Hallervorden-Spatz综合征）中，路易小体显示出对α-突触核蛋白/阿尔茨海默病淀粉样蛋白非Aβ成分前体的免疫染色，这表明除帕金森病外，α-突触核蛋白通常与其他散发性和家族性神经退行性疾病中路易小体的形成有关。
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