Mori H, Kondo T, Yokochi M, Matsumine H, Nakagawa-Hattori Y, Miyake T, Suda K, Mizuno Y
Department of Neurology, School of Medicine, Juntendo University, Tokyo, Japan.
Neurology. 1998 Sep;51(3):890-2. doi: 10.1212/wnl.51.3.890.
We report the results of pathologic and biochemical studies in a patient with 6q-linked autosomal recessive juvenile parkinsonism (AR-JP). Neuronal loss and gliosis were restricted to the substantia nigra and the locus ceruleus. No Lewy bodies were found, but neurofibrillary tangles and argyrophilic astrocytes were seen in the cerebral cortex and brainstem nuclei. The later findings, which have not been reported previously in AR-JP, suggest the pathologic heterogeneity of 6q-linked AR-JP.
我们报告了一名患有6号染色体连锁常染色体隐性少年帕金森病（AR-JP）患者的病理和生化研究结果。神经元丢失和胶质细胞增生仅限于黑质和蓝斑。未发现路易小体，但在大脑皮层和脑干核中可见神经原纤维缠结和嗜银性星形胶质细胞。这些先前在AR-JP中未被报道的后期发现提示了6号染色体连锁AR-JP的病理异质性。
