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Inhibition of long-term potentiation in developing rat visual cortex but not hippocampus by in utero exposure to polychlorinated biphenyls.

作者信息

Altmann L, Lilienthal H, Hany J, Wiegand H

机构信息

Medical Institute of Environmental Hygiene, Heinrich-Heine-Univ. Düsseldorf, Department of Neurotoxicology, Auf'm Hennekamp 50, D-40225, Düsseldorf, Germany.

出版信息

Brain Res Dev Brain Res. 1998 Oct 1;110(2):257-60. doi: 10.1016/s0165-3806(98)00112-6.

DOI:10.1016/s0165-3806(98)00112-6
PMID:9748615
Abstract

The neurotoxic potential of polychlorinated biphenyls (PCBs) depends on the structure of the congener as well as on the age of the exposure. We exposed rats prenatally to a coplanar congener (PCB-77) or to a non-coplanar congener (PCB-47) and measured the amount of long-term potentiation (LTP) at postnatal days 11-19 in the visual cortex and hippocampus. While PCB-77 exposure affected LTP statistically significantly in cortical but not hippocampal slices, the exposure to PCB-47 was much less effective.

摘要

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