Davis B J, Reed L A, Schelper R L
Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Eur Neurol. 1998 Oct;40(3):141-5. doi: 10.1159/000007970.
We present updated information on a previously reported kindred with an autosomal dominant disorder variably expressed as indifference to pain, dementia, and ataxia. Additional clinical and radiological information is presented, as are autopsy results form the index case. In addition to evidence of Alzheimer's disease, the autopsy revealed bilateral thalamic gliosis, which may be a neuroanatomic substrate for the indifference to pain seen in this patient. To our knowledge, this is the first reported association of thalamic gliosis and indifference to pain.
我们提供了关于一个先前报道的家族的最新信息，该家族患有常染色体显性疾病，其表现多样，包括对疼痛不敏感、痴呆和共济失调。文中呈现了更多的临床和放射学信息，以及索引病例的尸检结果。除了阿尔茨海默病的证据外，尸检还发现双侧丘脑神经胶质增生，这可能是该患者对疼痛不敏感的神经解剖学基础。据我们所知，这是首次报道的丘脑神经胶质增生与对疼痛不敏感之间的关联。
