[高脂血症患者血浆磷脂酰胆碱的脂肪酸组成及脂质与脂蛋白水平。II. 与β脂蛋白的关系]

[Fatty acid composition of plasma phosphatidylcholine and levels of lipids and lipoproteins in hyperlipoproteinemia. II. Relation with B lipoproteins].

作者信息

Zák A, Zeman M, Tvrzická E

机构信息

IV. interní klinika 1. LF UK a VFN, Praha.

出版信息

Cas Lek Cesk. 1998 Jun 29;137(13):400-3.

PMID:9748733

Abstract

BACKGROUND

Epidemiological trials provided evidence that the cholesterol concentration in lipoproteins B, i.e. VDL, IDL and LDL, correlate significantly with the incidence of ischaemic heart disease (IHD). The objective of the present study was to assess how the fatty acid composition in plasma phosphatidyl choline affects the total and LDL cholesterol, triglyceride and apolipoprotein B concentrations in subjects with primary hyperlipoproteinaemia and dyslipidaemia.

METHODS AND RESULTS

In a group of 142 subjects with primary hyperlipoproteinaemia and dyslipidaemia the concentrations of plasma lipids, lipoproteins apolipoproteins and fatty acids in plasma phosphatidyl choline (PC) were assessed. The authors provided evidence by discriminant analysis where the dependent variables were the lower quintiles (Q1 + Q2) and the upper quintiles (Q4 + Q5) of concentrations of total cholesterol, triglycerides, LDL-cholesterol and apolipoprotein B and the independent variables were FA concentrations in plasma PC, that the total cholesterol concentration was inversely associated with the concentration of docosahexaenic acid (22:6n-3). The concentration of LDL-cholesterol correlated inversely with the concentration of palmitoleic acid (16:1n-7). Triglyceridaemia was inversely associated with the linoleic acid concentration (18:2n-6). The concentration of apolipoprotein B correlated positively with myristic acid (14:0) and negatively with concentrations of oleic acid (18:1n-9) and linoleic acid (18:2n-6).

CONCLUSIONS

The submitted results indicate that the fatty acid concentrations of PC in plasma are significantly and markedly correlated with concentrations of total cholesterol, triglycerides, LDL-cholesterol and apolipoprotein B. It is possible that atherogenic lipoproteins may be favourably influenced not only by the amount of fat but also by a suitable fatty acid composition.

摘要

背景

流行病学试验表明，脂蛋白B（即极低密度脂蛋白、中间密度脂蛋白和低密度脂蛋白）中的胆固醇浓度与缺血性心脏病（IHD）的发病率显著相关。本研究的目的是评估原发性高脂血症和血脂异常患者血浆磷脂酰胆碱中的脂肪酸组成如何影响总胆固醇、低密度脂蛋白胆固醇、甘油三酯和载脂蛋白B的浓度。

方法与结果

对142例原发性高脂血症和血脂异常患者的血浆脂质、脂蛋白、载脂蛋白以及血浆磷脂酰胆碱（PC）中的脂肪酸浓度进行了评估。作者通过判别分析提供了证据，其中因变量为总胆固醇、甘油三酯、低密度脂蛋白胆固醇和载脂蛋白B浓度的较低五分位数（Q1 + Q2）和较高五分位数（Q4 + Q5），自变量为血浆PC中的脂肪酸浓度，结果显示总胆固醇浓度与二十二碳六烯酸（22:6n-3）浓度呈负相关。低密度脂蛋白胆固醇浓度与棕榈油酸（16:1n-7）浓度呈负相关。甘油三酯血症与亚油酸（18:2n-6）浓度呈负相关。载脂蛋白B浓度与肉豆蔻酸（14:0）呈正相关，与油酸（18:1n-9）和亚油酸（18:2n-6）浓度呈负相关。