Sedláková A, Kohút A
Ustav farmakológie Lekárskej fakulty Univerzity P.J. Safárika, Kosice.
Cesk Fysiol. 1998 Sep;47(3):95-103.
Phospholipase A2 (PLA2) hydrolyses membrane phospholipids (PL) and it may release arachidonic acid (AA)--the precursor of eicosanoids--from the sn-2 position. PLA2 and metabolites of its catalytic activity participate in many processes in the organism: metabolism of lipids, inflammation and immune reactions, membrane and tissue reparation, proliferation, and others. PLA2 as also an important element in the signal transduction. In the present article, PLA2 is characterised, classified into several types, and its mechanism of action together with its possible role in the disease processes are described. The attention is aimed at two forms of PLA2: The secretory (PLA2) of the type II which is associated with the inflammation injury, and the cytosolic PLA2 which is the main catalyst in the liberation of AA and which participates in the signal transduction. Other forms of PLA2 has been also described.
磷脂酶A2（PLA2）可水解膜磷脂（PL），并可能从sn-2位释放花生四烯酸（AA）——类二十烷酸的前体。PLA2及其催化活性的代谢产物参与机体的许多过程：脂质代谢、炎症和免疫反应、膜和组织修复、增殖等。PLA2也是信号转导中的重要元素。在本文中，对PLA2进行了表征，分为几种类型，并描述了其作用机制及其在疾病过程中可能发挥的作用。重点关注两种形式的PLA2：与炎症损伤相关的II型分泌型（PLA2），以及作为AA释放的主要催化剂并参与信号转导的胞质型PLA2。还描述了其他形式的PLA2。
