Thomsen L L, Olesen J, Russell M B
Neurologisk afdeling, Amtssygehuset i Glostrup.
Ugeskr Laeger. 1998 Sep 7;160(37):5325-9.
Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura. It is inherited as an autosomal dominant trait. A gene for FHM has been assigned to chromosome 19. This gene codes for a brain-specific calcium channel, and is responsible for FHM in 55% of the FHM families. Other FHM families have been linked to two different locations on chromosome 1. These locations contain possible candidate genes coding for calcium-and potassium channels. Thus FHM is a genetically heterogenous ion channel disorder, which is caused by at least three different genes. About 29% of the FHM families also have cerebellar ataxia, these families have all been linked to chromosome 19. The identification of the genes for FHM may be a key to the identification of the gene/genes for migraine with and without aura.
家族性偏瘫性偏头痛（FHM）是偏头痛伴先兆的一种罕见亚型。它作为常染色体显性性状遗传。FHM的一个基因已被定位于19号染色体。该基因编码一种脑特异性钙通道，在55%的FHM家族中导致FHM。其他FHM家族与1号染色体上的两个不同位置相关联。这些位置包含可能编码钙通道和钾通道的候选基因。因此，FHM是一种遗传异质性离子通道疾病，由至少三个不同基因引起。约29%的FHM家族也有小脑共济失调，这些家族均与19号染色体相关联。FHM基因的鉴定可能是鉴别有先兆和无先兆偏头痛基因的关键。
