腺苷-5'-α,β-亚甲基二膦酸对兔回肠纵行平滑肌的松弛作用。

The relaxant effect of adenosine-5'-alpha, beta-methylenediphosphonate on the longitudinal smooth muscle of the rabbit ileum.

作者信息

Frew R, McKenzie S G, Bär H P, Hutchison K J

出版信息

Can J Physiol Pharmacol. 1976 Aug;54(4):626-9. doi: 10.1139/y76-087.

Abstract

The response pattern of the isolated longitudinal muscle of the rabbit ileum to adenosine-5'-alpha, beta-methylenediphosphonate (APCP) was found to differ from that caused by adenosine or ATP in that the rapid initial phase of relaxation is absent and that at doses above 10 muM a secondary increase of contractile activity occurs in the continued presence of the nucleotide. This secondary phase was attenuated after indomethacin pretreatment and reestablishement of tone with acetylcholine. Theophylline did not modify APCP-induced relaxations while effectively antagonizing those caused by adenosine. It appears that APCP acts via a receptor site or pathway distinct from that of adenosine or ATP.

摘要

发现兔回肠孤立纵行肌对腺苷-5'-α,β-亚甲基二膦酸酯（APCP）的反应模式不同于腺苷或ATP所引起的反应模式，即不存在快速的初始舒张期，并且在核苷酸持续存在的情况下，当剂量高于10μM时，收缩活性会出现二次增加。吲哚美辛预处理并用乙酰胆碱恢复张力后，这一第二阶段会减弱。茶碱不会改变APCP诱导的舒张，而能有效拮抗腺苷引起的舒张。似乎APCP通过与腺苷或ATP不同的受体位点或途径起作用。