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[使用新一代碎石机在非同步模式下进行体外冲击波碎石术的致心律失常作用]

[Arrhythmogenic effects of extracorporal lithotripsy in desynchronized mode with a later generation lithotriptor].

作者信息

Ounnoughène Z, Duboc D, Le Heuzey J Y, Lazarus A, Varin J, Flam T, Debré B, Weber S

机构信息

Service de cardiologie, hôpital Cochin, Paris.

出版信息

Arch Mal Coeur Vaiss. 1998 Mar;91(3):317-22.

PMID:9749236
Abstract

Extracorporal lithotripsy has transformed the treatment of renal stones. However, the shock waves can generate arrhythmias which may be severe. To prevent them, the shocks were synchronised to the absolute refractory period of the cardiac cycle with a corollary, an increase in the procedure time. The latest generation of lithotriptors have a number of technical improvements allowing desynchronisation but with a high theoretic risk of arrhythmias. The aim of this study was to assess the arrhythmogenic effects of desynchronised shocks by Holter ECG monitoring during the procedure. This was a prospective randomised study: 25 patients with no previous cardiovascular history were included: 15 men and 10 women with a mean age of 45 years. The originality of this study was the delivery of shock waves in two phases (synchronised versus desynchronised) in a random fashion, the order being unknown to the cardiologist interpreting the recordings. In the synchronised mode, none of the patients developed an arrhythmia. On the other hand, in the desynchronised mode, hyperexcitability was observed in 7 patients, supraventricular in 6 cases (atrial extrasystoles and atrial doublets) and ventricular in 4 cases (VES, ventricular doublets and 1 unsustained ventricular tachycardia). These arrhythmias were asymptomatic and regressed spontaneously. The authors conclude that although they are arrhythmogenic, desynchronised procedures with the latest lithotriptors are acceptable, provided that the patients undergo a cardiological examination beforehand to identify high risk patients and that there is adequate monitoring during the procedure in the presence of an anaesthetist.

摘要

体外冲击波碎石术改变了肾结石的治疗方式。然而,冲击波可引发心律失常,且可能较为严重。为预防心律失常,曾将冲击波与心动周期的绝对不应期同步,但这导致治疗时间延长。最新一代的碎石机有多项技术改进,可实现非同步化,但理论上心律失常风险较高。本研究旨在通过术中动态心电图监测评估非同步冲击波的致心律失常作用。这是一项前瞻性随机研究:纳入25例既往无心血管病史的患者,其中15例男性和10例女性,平均年龄45岁。本研究的独特之处在于以随机方式分两个阶段(同步与非同步)发放冲击波,解读记录的心脏病专家不知晓发放顺序。在同步模式下,无患者发生心律失常。另一方面,在非同步模式下,7例患者出现兴奋性增高,其中6例为室上性(房性早搏和房性二联律),4例为室性(室性早搏、室性二联律和1次非持续性室性心动过速)。这些心律失常无症状且可自发消退。作者得出结论,尽管最新的碎石机进行非同步操作有致心律失常作用,但只要患者术前接受心脏检查以识别高危患者,且术中在麻醉师在场的情况下进行充分监测,这种操作是可以接受的。

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