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[低剂量γ辐射对小鼠体内骨髓嗜多染红细胞细胞遗传损伤的作用]

[Action of low doses of gamma-radiation on cytogenetic damage in polychromatophilic erythrocytes of bone marrow in mice in vivo].

作者信息

Zaichkina S I, Klokov D Iu, Rozanova O M, Aptikaeva G F, Akhmadieva A Kh

机构信息

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow, Russia.

出版信息

Genetika. 1998 Jul;34(7):1013-6.

PMID:9749345
Abstract

The frequency of micronuclei was estimated in bone marrow polychromatic erythrocytes (PCEs) of mice gamma-irradiated in vivo at doses of 5-50 cGy. The dose-effect curve was found to have a complex stepwise pattern with three consequent segments: (1) high radiosensitivity, (2) a significant decrease in radiosensitivity, and (3) an increase in radiosensitivity.

摘要

对体内接受5 - 50 cGy剂量γ射线照射的小鼠骨髓嗜多染红细胞(PCEs)中的微核频率进行了估计。发现剂量效应曲线具有复杂的逐步模式,由三个连续的部分组成:(1)高放射敏感性,(2)放射敏感性显著降低,以及(3)放射敏感性增加。

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