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[胼胝体完全切断后猫联合皮质神经元结构的功能重组]

[Functional reorganizations of the neuronal structures of the cat associative cortex after total sectioning of the corpus callosum].

作者信息

Gabibov I M, Solnushkin S D

机构信息

Pavlov Institute of Physiology, St.-Petersburg.

出版信息

Usp Fiziol Nauk. 1998 Jul-Sep;29(3):21-34.

PMID:9749455
Abstract

In given work results of researches functional organization of neural networks at associative cortex level in intact and after total corpus callosum section (Cc sec) of cat's brain. In result of the given researches is established, that after total Cc sec the brain is exposed significant morphological and functional changes. Is shown, that Cc sec is accompanied by infringements in act of reception of food and head orientation of the animal in space. A configuration and characteristics varies conducting ways, opportunity of an exchange the information between is lost by hemispheres, and accordingly, to receive the information from ipsilateral hemifield of vision. The structural and functional characteristics vary of neural structures of both hemispheres: asymmetry of hemispheres in size disappears, orientational and directional characteristics and decreases number of subzones in receptive fields (RF). In RF of this area occur extensive inhibitory zones. Arrangements RF in vision field main borrows contralateral hemifield of vision, in intact a brain large part RF pass in ipsilateral hemifield of vision. Thus in result of these researches is established, that the majority of neural functions of left and right hemispheres at level associative cortex, revealed on intact brain are formed for account transcallosal of connections. In conditions of isolated functioning both hemispheres there are the changes as in ways of the information processing, and in complementary ways of display of space. In result callosotomy of neuron networks in both hemispheres undergo essential changes: the hemispheres lose ability to integrate the set of the parties of subjects, disturbed an opportunity of invariant the descriptions of images, hence the description of the space information occurs on separate attributes of this information.

摘要

在给定的研究工作中,研究了猫脑完整状态下以及完全胼胝体切断(Cc切断)后联合皮质水平神经网络的功能组织结果。这些研究结果表明,完全Cc切断后,大脑会出现显著的形态和功能变化。结果显示,Cc切断伴随着动物进食行为和空间头部定向的障碍。传导通路的构型和特征发生变化,半球间信息交换的机会丧失,相应地,无法从同侧视野接收信息。两侧半球神经结构的结构和功能特征也发生变化:半球大小的不对称消失,定向和方向特征改变,感受野(RF)中的子区域数量减少。在该区域的RF中出现广泛的抑制区。视野中RF的分布主要占据对侧视野,在完整大脑中,大部分RF延伸至同侧视野。因此,这些研究结果表明,在完整大脑中揭示的左右半球在联合皮质水平的大多数神经功能是通过胼胝体连接形成的。在两侧半球独立运作的情况下,信息处理方式以及空间表征的互补方式都会发生变化。胼胝体切断导致两侧半球的神经网络发生本质变化:半球失去整合物体各部分特征集的能力,图像不变性描述的机会受到干扰,因此空间信息的描述基于该信息的单独属性进行。

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