Miyazoe S, Matsuo H, Ohnishi A, Tajima F, Fujishita S, Ichinose K, Shibuya N
Department of Neurology, Kawatana National Hospital, Nagasaki, Japan.
Ann Neurol. 1998 Sep;44(3):378-81. doi: 10.1002/ana.410440314.
The pathogenesis and underlying lesion of acquired idiopathic generalized anhidrosis (AIGA) are apparently heterogeneous. We report a patient with AIGA in whom the eccrine glands were histologically normal. However, electron microscopic examination showed markedly low numbers of nerve terminals and unmyelinated axons associated with the eccrine glands. Our laboratory investigations suggest that degeneration of postganglionic sympathetic cholinergic nerve may be the underlying pathogenetic mechanism of anhidrosis in this patient.
获得性特发性全身性无汗症（AIGA）的发病机制和潜在病变显然具有异质性。我们报告了一名AIGA患者，其汗腺在组织学上正常。然而，电子显微镜检查显示与汗腺相关的神经末梢和无髓鞘轴突数量明显减少。我们的实验室研究表明，节后交感胆碱能神经变性可能是该患者无汗症的潜在发病机制。
