Yuki N, Yamamoto T, Hirata K
Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan.
Ann Neurol. 1998 Sep;44(3):408-10. doi: 10.1002/ana.410440321.
IgM anti-myelin-associated glycoprotein (anti-MAG)/sulfated glucuronyl paragloboside (SGPG) antibody is found in some patients with chronic polyneuropathy (CP). An antigen-driven process is considered to induce this autoantibody, but the agent has yet to be identified. It has been reported that sera from cytomegalovirus (CMV)-infected patients contained anti-SGPG antibody. To clarify the mechanism of the production of the anti-MAG/SGPG antibody, we investigated CMV DNA in sera from 26 patients with IgM anti-MAG/SGPG antibody-positive CP. Twenty-three (88%) had CMV DNA. The positive frequency was significantly higher than the frequencies in sera from patients with IgM anti-MAG/SGPG-negative CP, the other disease controls, and the normal control subjects. There were no statistical differences in the frequencies of Epstein-Barr virus DNA between anti-MAG/SGPG-positive and anti-MAG/SGPG-negative CP and between anti-MAG/SGPG-positive CP and each disease control. Moreover, no herpes simplex virus 1 DNA was detected in the sera from patients with anti-MAG/SGPG-positive CP. The strong correlation of anti-MAG/SGPG-positive CP with the presence of serum CMV DNA suggests that CMV infection induces the IgM anti-MAG/SGPG antibody.
在一些慢性多发性神经病（CP）患者中发现了IgM抗髓鞘相关糖蛋白（抗MAG）/硫酸化葡糖醛酸副球蛋白（SGPG）抗体。抗原驱动过程被认为可诱导产生这种自身抗体，但该病原体尚未确定。据报道，巨细胞病毒（CMV）感染患者的血清中含有抗SGPG抗体。为阐明抗MAG/SGPG抗体的产生机制，我们检测了26例IgM抗MAG/SGPG抗体阳性CP患者血清中的CMV DNA。其中23例（88%）检测到CMV DNA。其阳性频率显著高于IgM抗MAG/SGPG阴性CP患者、其他疾病对照者及正常对照者血清中的频率。抗MAG/SGPG阳性与抗MAG/SGPG阴性CP患者之间以及抗MAG/SGPG阳性CP患者与各疾病对照者之间，EB病毒DNA频率无统计学差异。此外，抗MAG/SGPG阳性CP患者血清中未检测到单纯疱疹病毒1型DNA。抗MAG/SGPG阳性CP与血清CMV DNA存在之间的强相关性表明，CMV感染可诱导产生IgM抗MAG/SGPG抗体。
