Dejardin S, Dubois S, Bodart J M, Schiltz C, Delinte A, Michel C, Roucoux A, Crommelinck M
Laboratory of Neurophysiology, University of Louvain 5449, Brussels, Belgium.
Eur J Neurosci. 1998 Jul;10(7):2328-36. doi: 10.1046/j.1460-9568.1998.00245.x.
Using H2(15)O 3D Positron Emission Tomography (PET), regional cerebral blood flow (rCBF) was measured in six human subjects under two different conditions: at rest and while performing self-paced horizontal saccadic eye movements in darkness. These two conditions were repeated four times each. First, the comparison between the four saccadic and four resting conditions was investigated in a group and a single subject analysis. Saccades elicited bilateral rCBF increases in the medial part of the superior frontal gyrus (supplementary eye field), precentral gyrus (frontal eye field), superior parietal lobule, anterior medial part of the occipital lobe involving striate and extrastriate cortex (lingual gyrus and cuneus), and in the right inferior parietal lobule. At the subcortical level, activations were found in the left putamen. These results mainly replicate previous PET findings on saccadic control. Second, the interaction between the experimental conditions and their repetition was examined. When activations throughout repetition of the same saccadic task are compared, the supplementary eye fields show a progressive increase of activation. On the contrary, the activation in the cerebellum, left superior parietal lobule and left occipital cortex progressively decreases during the scanning session. Given the existence of such an interaction, the pattern of activations must be interpreted as a function of task repetition. This may be a factor explaining some apparent mismatch between different studies.
利用H₂(¹⁵)O三维正电子发射断层扫描（PET）技术，在两种不同条件下对6名人类受试者的局部脑血流量（rCBF）进行了测量：一种是静息状态，另一种是在黑暗中进行自我调节的水平眼球扫视运动时。这两种条件各重复4次。首先，在组分析和单受试者分析中研究了4次扫视条件和4次静息条件之间的比较。扫视运动引起双侧额上回内侧部分（辅助眼区）、中央前回（额叶眼区）、顶上小叶、枕叶前内侧部分（包括纹状皮层和纹外皮层，舌回和楔叶）以及右侧顶下小叶的rCBF增加。在皮层下水平，左侧壳核出现激活。这些结果主要重复了先前关于扫视控制的PET研究结果。其次，研究了实验条件及其重复之间的相互作用。当比较同一扫视任务重复过程中的激活情况时，辅助眼区的激活呈现出逐渐增加的趋势。相反，在扫描过程中，小脑、左侧顶上小叶和左侧枕叶皮层的激活逐渐减少。鉴于存在这种相互作用，激活模式必须作为任务重复的函数来解释。这可能是解释不同研究之间一些明显不匹配的一个因素。
