Dehner L P, Askin F B
Cancer. 1976 Aug;38(2):888-900. doi: 10.1002/1097-0142(197608)38:2<888::aid-cncr2820380236>3.0.co;2-r.
Fibroblastic lesions in children present difficulties in diagnosis and in a justifiable therapeutic approach. This series reviews the clinical and pathologic features of fibroblastic soft tissue lesions from 66 children. Although radical procedures were occasionally required to achieve local control of an aggressive lesion, conservative surgery was generally successful. Recurrences were frequent, but only one lesion, in an adolescent, metastasized. No prognostic value could be found in anatomic location or in histologic features. Even cellular lesions with frequent mitoses ordinarily did not require the aggressive therapy needed in similar lesions in adults. In this series, incomplete original excision was frequent and usually related to the infiltrating margins of the lesion.
儿童纤维母细胞性病变在诊断和合理的治疗方法上存在困难。本系列回顾了66例儿童纤维母细胞性软组织病变的临床和病理特征。尽管偶尔需要采取根治性手术来实现对侵袭性病变的局部控制，但保守手术总体上是成功的。复发很常见，但只有1例青少年病变发生了转移。在解剖位置或组织学特征中未发现预后价值。即使是有频繁核分裂的细胞性病变，通常也不需要像成人类似病变那样采取积极的治疗。在本系列中，初始切除不完全很常见，且通常与病变的浸润边缘有关。
