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肿瘤治疗后男性不育的治疗:预防性自体精子保存与睾丸活检及利用睾丸精子进行卵母细胞受精

[Treatment of male infertility after oncologic therapy: preventive autologous sperm preservation versus testicular biopsy and oocyte fertilization with testicular spermatozoa].

作者信息

Sobek A, Mucha Z, Hrbková K, Pernicka J, Zát'ura F, Vodicka J, Dokoupilová M, Scheinar J

机构信息

FERTIMED-centrum pro lécbu neplodnosti, Olomouc.

出版信息

Ceska Gynekol. 1998 Jun;63(3):196-9.

PMID:9750379
Abstract

The prognosis of oncological therapy of some malignancies is favourable. Unfortunately the majority of young patients remain sterile. Sperm cryopreserved before treatment was successfully used in IVF-ICSI (in vitro fertilization-intracytoplasmic sperm injection) cycles. Testicular biopsy (TESE) was performed after successful oncological treatment in three men without previous sperm cryopreservation. No spermatozoa were found for oocyte fertilization. TESE could not ensure sperm recovery in all patients after oncological treatment. Sperm cryopreservation should be highly recommended to all patients before any treatment is offered.

摘要

某些恶性肿瘤的肿瘤治疗预后良好。不幸的是,大多数年轻患者会保持不育状态。治疗前冷冻保存的精子已成功应用于体外受精-卵胞浆内单精子注射(IVF-ICSI)周期。在三名先前未进行精子冷冻保存的男性成功完成肿瘤治疗后,进行了睾丸活检(TESE)。未发现用于卵母细胞受精的精子。TESE不能确保所有肿瘤治疗后的患者都能恢复精子。强烈建议所有患者在接受任何治疗前进行精子冷冻保存。

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