Kakehi Y
Department of Urology, Faculty of Medicine, Kyoto University.
Nihon Rinsho. 1998 Aug;56(8):1969-73.
The incidence rate of clinically manifest prostate cancer in 1992 was estimated 15.7 per 100,000 men, although it is increasing exponentially. Accordingly, 5399 deaths from prostate cancer in 1995 will be increased to 13,494 deaths in 2015. Change in dietary habit (more Western-style diet) is considered to be a major cause of the increase. Escalating number of elderly people in the Japanese population is another major reason of elevated incidence. On the other, public awareness of prostate cancer and introduction of serum PSA measurement to health check-up undoubtedly have raised the detection rate of early stage disease. The way of androgen ablation do not seem to have influenced on survival of the advanced disease so far. It remains to be clarified whether the combined androgen blockade using pure anti-androgens with castration provide better patients' survival than castration alone.
1992年临床确诊的前列腺癌发病率估计为每10万名男性中有15.7例，尽管其呈指数级增长。因此，1995年因前列腺癌死亡的5399人到2015年将增至13494人。饮食习惯的改变（更多西式饮食）被认为是增长的主要原因。日本人口中老年人数量的不断增加是发病率升高的另一个主要原因。另一方面，公众对前列腺癌的认识以及将血清PSA检测引入健康检查无疑提高了早期疾病的检出率。到目前为止，雄激素剥夺的方式似乎并未影响晚期疾病的生存率。使用纯抗雄激素药物与去势联合进行雄激素阻断是否比单纯去势能为患者提供更好的生存效果仍有待阐明。
