Kawai K, Akaza H
Department of Urology, University of Tsukuba.
Nihon Rinsho. 1998 Aug;56(8):2108-13.
Luteinizing hormone-releasing hormone (LHRH) analogue therapy is one of the most widely used hormonal therapy for prostate cancer. LHRH analogue is effective and safety therapy for prostate cancer, when appropriate consideration is given to the disease flare. Recently, new long acting 3-month LHRH analogue depot has been developed and showed the therapeutic equivalence to the 1-month depot. In basic research, the expression of LHRH and its receptor has been demonstrated in some kinds of hormone depend cancer including prostate cancer. Although precise role of LHRH system in those cancers remains unclear, these findings suggests the presence of an autocrine system based on LHRH. More understanding of LHRH system might provide new treatment approaches to those cancer.
促黄体生成激素释放激素（LHRH）类似物疗法是前列腺癌最广泛使用的激素疗法之一。LHRH类似物对前列腺癌是一种有效且安全的疗法，但需适当考虑疾病发作情况。最近，新型长效3个月LHRH类似物长效注射剂已研发出来，并显示出与1个月长效注射剂具有治疗等效性。在基础研究中，已证实在包括前列腺癌在内的某些激素依赖性癌症中存在LHRH及其受体的表达。尽管LHRH系统在这些癌症中的精确作用仍不清楚，但这些发现提示存在基于LHRH的自分泌系统。对LHRH系统的更多了解可能为这些癌症提供新的治疗方法。
