一项针对一家钢铁制造厂膀胱癌发病率的巢式病例对照研究。
A nested case-control study of bladder cancer incidence in a steel manufacturing plant.
作者信息
Mallin K
机构信息
Division of Epidemiology-Biostatistics, University of Illinois at Chicago, School of Public Health 60612, USA.
出版信息
Am J Ind Med. 1998 Oct;34(4):393-8. doi: 10.1002/(sici)1097-0274(199810)34:4<393::aid-ajim14>3.0.co;2-y.
BACKGROUND
A surveillance study of bladder cancer incidence in northwestern Illinois detected a number of cases who had worked in a large steel manufacturing plant. To investigate these cancers further, a nested case-control study of bladder cancer was conducted at this plant.
METHODS
Cases from the surveillance study were matched to company personnel files. Four controls per case were selected from company files and frequency matched on age (cases and controls were all white males). Employment histories were abstracted from company records and odds ratios calculated according to job titles and departments worked. Cases and controls who held only white collar jobs were excluded from the analysis.
RESULTS
Results for 16 cases and 75 controls showed elevated odds ratios for heaters (OR = 21.1, 95% cCI = 2.2-205.8) based on three cases. Heaters monitored electric reheat furnaces and may have been exposed to polycyclic aromatic hydrocarbons. Previous studies have shown moderate risks for bladder cancer among furnace operators, but most of these studies were also based on a small number of cases.
CONCLUSIONS
Additional studies of furnace operators' exposures and cancer risks are needed to investigate these results further.
背景
一项对伊利诺伊州西北部膀胱癌发病率的监测研究发现，有许多病例曾在一家大型钢铁制造厂工作。为了进一步调查这些癌症病例，在这家工厂开展了一项膀胱癌巢式病例对照研究。
方法
监测研究中的病例与公司人事档案进行匹配。从公司档案中为每个病例选取4名对照，并按照年龄进行频数匹配（病例和对照均为白人男性）。从公司记录中提取就业史，并根据工作职位和所在部门计算比值比。仅从事白领工作的病例和对照被排除在分析之外。
结果
16例病例和75名对照的结果显示，基于3例病例，加热器岗位的比值比升高（比值比=21.1，95%置信区间=2.2-205.8）。加热器负责监控电再热炉，可能接触过多环芳烃。以往研究表明，熔炉操作工患膀胱癌的风险中等，但其中大多数研究也基于少数病例。
结论
需要对熔炉操作工的接触情况和癌症风险进行更多研究，以进一步调查这些结果。
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