Koszycki D, Zacharko R M, Le Mellédo J M, Bradwejn J
Stress and Anxiety Clinical Research Unit, Royal Ottawa Hospital, Ontario, Canada.
Depress Anxiety. 1998;8(1):1-7.
Healthy subjects who panic following systemic cholecystokinin-tetrapeptide (CCK-4) challenge typically exhibit a symptom profile reminiscent of that evident among panic patients. However, the biological concomitants of CCK-4-induced panic in healthy subjects remain obscure. Accordingly, we evaluated the behavioral, cardiovascular, and neuroendocrine effects of CCK-4 in panickers and nonpanickers. Predictably, subjects who panicked with CCK-4 experienced more intense symptoms of panic and greater increases in ratings of fearful and anxious mood than did subjects who did not panic. CCK-4-induced increases in diastolic blood pressure, adrenocorticotropic hormone, prolactin, and growth hormone secretion were also significantly enhanced in subjects who panicked. The results of this study demonstrate that the behavioral experience of CCK-4-induced panic in healthy individuals is accompanied by marked biological changes and provide confirmation that CCK-4 is a useful model of panic for research among nonclinical subjects.
在全身性胆囊收缩素四肽（CCK-4）激发试验后出现惊恐发作的健康受试者，其典型症状与惊恐障碍患者的症状相似。然而，CCK-4诱发健康受试者惊恐发作的生物学伴随现象仍不清楚。因此，我们评估了CCK-4对惊恐发作组和非惊恐发作组受试者行为、心血管及神经内分泌的影响。不出所料，与未出现惊恐发作的受试者相比，CCK-4诱发惊恐发作的受试者经历了更强烈的惊恐症状，且恐惧和焦虑情绪评分增加幅度更大。在出现惊恐发作的受试者中，CCK-4诱发的舒张压、促肾上腺皮质激素、催乳素及生长激素分泌增加也显著增强。本研究结果表明，健康个体中CCK-4诱发惊恐发作的行为体验伴随着显著的生物学变化，并证实CCK-4是研究非临床受试者惊恐障碍的有用模型。
