环磷酸腺苷（cAMP）会削弱催乳素（PRL）对碘摄取进入小鼠乳腺组织的刺激作用。

Cyclic AMP impairs the PRL stimulation of iodide uptake into mouse mammary tissues.

作者信息

Rillema J A, Marting C

机构信息

Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.

出版信息

Proc Soc Exp Biol Med. 1998 Oct;219(1):37-40. doi: 10.3181/00379727-219-44313.

DOI:10.3181/00379727-219-44313

PMID:9751220

Abstract

In earlier studies the uptake of iodide into mammary cells was found to occur by a mechanism similar to that in thyroid cells (i.e., the uptake occurs via a sodium-iodide symporter that is inhibited by perchlorate and thiocyanate). Although cyclic AMP stimulates the iodide transport mechanism in thyroid cells, the present studies show that cyclic AMP, as well as pharmacological agents that elevate cyclic AMP, impair iodide uptake into mammary cells. In addition, elevated cyclic AMP levels interfere with the PRL stimulation of iodide uptake as well as iodide incorporation into proteins in mammary tissues. Clearly, cyclic AMP has opposite effects on regulating iodide uptake processes in mammary versus thyroid cells.

摘要

在早期研究中发现，碘化物进入乳腺细胞的机制与甲状腺细胞相似（即通过钠-碘同向转运体摄取，该转运体可被高氯酸盐和硫氰酸盐抑制）。虽然环磷酸腺苷（cAMP）可刺激甲状腺细胞中的碘化物转运机制，但目前的研究表明，cAMP以及能提高cAMP水平的药物制剂会损害碘化物进入乳腺细胞的过程。此外，cAMP水平升高会干扰催乳素（PRL）对乳腺组织中碘化物摄取以及碘化物掺入蛋白质过程的刺激作用。显然，cAMP在调节乳腺细胞与甲状腺细胞的碘化物摄取过程中具有相反的作用。