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一种用于制备[(111)In]铟-二乙三胺五乙酸-叶酸(一种叶酸受体靶向放射性药物)的试剂盒配方。

A kit formulation for preparation of [(111)In]In-DTPA-folate, a folate-receptor-targeted radiopharmaceutical.

作者信息

Mathias C J, Green M A

机构信息

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907-1333, USA.

出版信息

Nucl Med Biol. 1998 Aug;25(6):585-7. doi: 10.1016/s0969-8051(98)00030-4.

Abstract

A kit formulation has been developed for convenient, routine compounding of (111)In-labeled In(III)-DTPA-Folate, an investigational radiopharmaceutical for targeting tumor-associated folate receptors. The kit consists of the DTPA-Folate conjugate in sodium citrate solution, from which [(111)In]In-DTPA-Folate can be rapidly and reliably compounded by the addition of aqueous [(111)In]In(III)-chloride.

摘要

已开发出一种试剂盒配方,用于方便、常规地配制(111)铟标记的铟(III)-二乙三胺五乙酸-叶酸,这是一种用于靶向肿瘤相关叶酸受体的研究用放射性药物。该试剂盒由柠檬酸钠溶液中的二乙三胺五乙酸-叶酸共轭物组成,通过加入氯化(111)铟水溶液,可快速、可靠地配制出[(111)铟]铟-二乙三胺五乙酸-叶酸。

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