Berger A, Piqueras B, Pages F, Tartour E, Cugnenc P H, Fridman W H
Service de chirurgie générale, digestive et oncologique, Hôpital Laennec, Paris.
Bull Cancer. 1998 Feb;85(2):129-33.
Fas and Fas ligand (FasL) are implicated in programmed cell death or apoptosis. In the immunological field, they are particularly important in auto-immunity, graft rejection and anti-tumoral response. Fas ligand expression on thymocytes, activated T lymphocytes, and in sites of immune privilege, suggests the importance of Fas/FasL interactions in negative control of the immune response. The recent description of FasL expression by tumoral cells, represents a new mechanism of immune escape for different cancer, and has been well studied in colon adenocarcinoma.
Fas和Fas配体（FasL）与程序性细胞死亡或凋亡有关。在免疫学领域，它们在自身免疫、移植排斥和抗肿瘤反应中尤为重要。胸腺细胞、活化的T淋巴细胞以及免疫豁免部位的Fas配体表达，表明Fas/FasL相互作用在免疫反应的负调控中具有重要意义。肿瘤细胞FasL表达的最新描述，代表了不同癌症免疫逃逸的一种新机制，并且在结肠腺癌中已得到充分研究。
