Sato T, Yoshinouchi T, Sugimoto T, Sakamoto T, Fujieda H, Sato H, Murao S, Kobayashi H, Ohe T
Department of Cardiovascular Medicine, Matsuyama Shimin Hospital, Ehime.
J Cardiol. 1998 Aug;32(2):77-82.
The use of hepatocyte growth factor for acute myocardial infarction was investigated. Several other biochemical markers are already used for noninvasive detection of acute myocardial infarction. Hepatocyte growth factor, creatine phosphokinase (CK) and CK isozyme (CK-MB) levels were measured in 10 patients with stable effort angina after diagnostic catheterization, and in 21 patients with acute myocardial infarction twice a day for the first 3 days and once a day for the next 4 days. The time to reach the maximum level and the time to decline to less than half of the maximum level for each patient was also measured. Hepatocyte growth factor levels (ng/ml) were 0.3 +/- 0.1 for patients with angina pectoris, and 10.4 +/- 8.8 within 6 hours and 6.7 +/- 4.5 within 12 hours after the onset for patients with acute myocardial infarction. The time to reach the maximum (hours) and the time to decline to less than half of the maximum level (days) were 9.2 +/- 5.2 and 1.1 +/- 0.3 for hepatocyte growth factor, 19.5 +/- 7.2 and 2.3 +/- 1.1 for CK and 16.3 +/- 7.2 and 1.5 +/- 0.4 for CK-MB, respectively. The correlation coefficients between the maximum level of hepatocyte growth factor and the maximum levels of CK and CK-MB were 0.64 and 0.70, respectively. Hepatocyte growth factor is useful as a prognostic indicator and reflects the clinical course in patients with acute myocardial infarction.
对肝细胞生长因子用于急性心肌梗死进行了研究。其他几种生化标志物已用于急性心肌梗死的无创检测。对10例经诊断性心导管插入术后患有稳定劳力性心绞痛的患者，以及21例急性心肌梗死患者，在最初3天每天检测两次肝细胞生长因子、肌酸磷酸激酶（CK）和CK同工酶（CK-MB）水平，接下来4天每天检测一次。还测量了每位患者达到最高水平的时间以及降至最高水平一半以下的时间。心绞痛患者的肝细胞生长因子水平（ng/ml）为0.3±0.1，急性心肌梗死患者在发病后6小时内为10.4±8.8，12小时内为6.7±4.5。肝细胞生长因子达到最高水平的时间（小时）和降至最高水平一半以下的时间（天）分别为9.2±5.2和1.1±0.3，CK分别为19.5±7.2和2.3±1.1，CK-MB分别为16.3±7.2和1.5±0.4。肝细胞生长因子最高水平与CK和CK-MB最高水平之间的相关系数分别为0.64和0.70。肝细胞生长因子可用作预后指标，并反映急性心肌梗死患者的临床病程。
