Kate V, Ananthakrishnan N, Badrinath S, Amarnath S K, Ratnakar C
Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Trop Gastroenterol. 1998 Apr-Jun;19(2):75-7.
One hundred and three patients were included in the study. Thirty seven had duodenal ulcer (DU) (Group I), 35 DU with gastric outlet obstruction (GOO) with presence of an active ulcer in the duodenum (Group II). Thirty one had DU with GOO but no active ulcer (Group III). Presence of H. pylori infection was determined by urease test, serology and/or histology. The prevalence of H. pylori in these groups was compared. Levels of Anti-H. pylori IgG antibody titres were also compared. The patients with duodenal ulcer (DU) were significantly younger (38 +/- 2 years) compared to those with established gastric outlet obstruction without ulcer (45 +/- 2 years) (P = 0.02). The prevalence of H. pylori infection in DU (95%), DU with GOO with ulcer (91%) and DU with GOO but no ulcer (90%) was not significantly different (p > 0.05). Anti-H. pylori IgG antibody titre levels were 72 +/- 6 EU/ml in Group III. The titre levels between Group I and Group III were significantly different (P < 0.05). The prevalence of H. pylori infection is high is patients with DU and is unaltered by gastric outlet obstruction. The presence or absence of an active ulcer with gastric outlet obstruction does not affect its association with H. pylori infection.
本研究纳入了103例患者。37例患有十二指肠溃疡（DU）（第一组），35例患有十二指肠溃疡伴胃出口梗阻（GOO）且十二指肠存在活动性溃疡（第二组）。31例患有十二指肠溃疡伴胃出口梗阻但无活动性溃疡（第三组）。通过尿素酶试验、血清学和/或组织学确定幽门螺杆菌感染情况。比较这些组中幽门螺杆菌的患病率。还比较了抗幽门螺杆菌IgG抗体滴度水平。十二指肠溃疡（DU）患者（38±2岁）比患有无溃疡的已确诊胃出口梗阻患者（45±2岁）明显年轻（P = 0.02）。DU中幽门螺杆菌感染率（95%）、伴有溃疡的十二指肠溃疡伴GOO（91%）和伴有GOO但无溃疡的十二指肠溃疡（90%）无显著差异（p>0.05）。第三组抗幽门螺杆菌IgG抗体滴度水平为72±6 EU/ml。第一组和第三组之间的滴度水平有显著差异（P<0.05）。DU患者中幽门螺杆菌感染率很高，且不受胃出口梗阻的影响。胃出口梗阻时有无活动性溃疡并不影响其与幽门螺杆菌感染的关联。
